Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.

David E Graham, Robert H White

Journal: Natural product reports 2002;19(2):133-47

PMID: 12013276

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Methanogenesis, the anaerobic production of methane from CO2 or simple carbon compounds, requires seven organic coenzymes. This review describes pathways for the biosynthesis of methanofuran, 5,6,7,8-tetrahydromethanopterin, coenzyme F420, coenzyme M (2-mercaptoethanesulfonic acid) and coenzyme B (7-mercaptoheptanoyl-L-threonine phosphate). Spectroscopic evidence for the pathways is reviewed and recent efforts are described to identify and characterize the biosynthetic enzymes from methanogenic archaea. The literature from 1971 to September 2001 is reviewed, and 169 references are cited.

Address: Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0308, USA.

DOI: 10.1039/b103714p

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https://doi.org/10.1039/b103714p

MeSH Terms: Archaea, Carbon Dioxide, Coenzymes, Diterpenes, Euryarchaeota, Furans, Genomics, Magnetic Resonance Spectroscopy, Mesna, Methane, Molecular Structure, Phosphothreonine, Pterins, Riboflavin