George P Chrousos, Konstantinos Albanopoulos, Geronikolou S, Athanassia Pavlopoulou, George I Lambrou, John Koutelekos, Dennis Cokkinos
Abstract
[{"label":"BACKGROUND","text":"Kisspeptin (encoded by the KISS1 gene in humans) is an excitatory neuromodulatory peptide implicated in multiple homeostatic systems, including anti-oxidation, glucose homeostasis, nutrition, locomotion, etc. Therefore, in the current obesity epidemic, kisspeptin is gaining increasing interest as a research objective."},{"label":"AIM","text":"To construct an updated interactome of genetic obesity, including the kisspeptin signal transduction pathway."},{"label":"METHODS","text":"Kisspeptin and obesity-related genes or gene products were extracted from the biomedical literature, and a network of functional associations was created."},{"label":"RESULTS","text":"The generated network contains 101 nodes corresponding to gene\/gene products with known and\/or predicted interactions. In this interactome, KISS1 and KISS1R are connected directly to the luteinizing hormone receptor (LHCGR), gonadotropin-releasing hormone receptor (GNRH1), and indirectly, through the latter, to proopiomelanocortin (POMC), glucagon, leptin (LEP), and\/or pro-protein convertase subtilisin\/kexin-type 1 (PCSK1), all of which are critically implicated in obesity disorders."},{"label":"CONCLUSIONS","text":"Our updated obesidome includes kisspeptin and its connections to the genetic obesity signalosome with 12 major hubs: glucagon (GCG), insulin (INS), arginine vasopressin (AVP), G protein subunit beta 1 (GNB1) and proopiomelanocortin (POMC), melanocortin 4 receptor (MC4R), leptin (LEP), gonadotropin-releasing hormone 1 (GNRH1), adrenoceptor beta 2 and 3 (ADRB2-3), glucagon-like peptide 1 receptor (GLP1R), and melanocortin 3 receptor (MC3R) genes were identified as major \"hubs\" for genetic obesity, providing novel insight into the body's energy homeostasis."},{"copyright":"\u00a9 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG."}]
Address:
Biomedical Research Foundation of Academy of Athens, Clinical, Translational, Experimental Surgery Research Center, Athens, Greece.
[email protected].; Izmir International Biomedicine and Genome Institute, Dokuz Eylül University; Izmir Biomedicine and Genome Center (IBG), Izmir, Turkey.; National and Kapodistrian University of Athens, First Department of Pediatrics, Choremeio Research Lambrou, Athens, Greece.
[email protected].; Nursing Department, School of Health Care, University of West Attica, Athens, Greece.; Biomedical Research Foundation of Academy of Athens, Clinical, Translational, Experimental Surgery Research Center, Athens, Greece.; First Propaedeutic Clinic of Surgery, Hippokrateion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.; University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens, Athens, Greece.
