Total-body PET Imaging: A New Frontier for the Assessment of Metabolic Disease and Obesity.

Maria Chondronikola, Souvik Sarkar

Journal: PET clinics 2021;16(1):75-87

PMID: 33160928

Full Text on Elsevier Science View on PubMed

Abstract

Obesity and associated metabolic syndrome are a global public health issue. Understanding the pathophysiology of this systemic disease is of critical importance for the development of future therapeutic interventions to improve clinical outcomes. The multiorgan nature of the pathophysiology of obesity presents a unique challenge. Total-body PET imaging, either static or dynamic, provides a vital set of tools to study organ crosstalk. The visualization and quantification of tissue metabolic kinetics with total-body PET in health and disease provides essential information to better understand disease physiology and potentially develop diagnostic and therapeutic modalities.

Address: Department of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA; Harokopio University of Athens, El Venizelou 70, Kallithea 17676, Greece.; Harokopio University of Athens, El Venizelou 70, Kallithea 17676, Greece; Division of Gastroenterology and Hepatology, University of California Davis, Davis, CA, USA. Electronic address: [email protected].

DOI: 10.1016/j.cpet.2020.09.001

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MeSH Terms: Humans, Metabolic Diseases, Obesity, Positron-Emission Tomography, Whole Body Imaging