Mind Over Magnets - How Magnetic Particle Imaging is Changing the Way We Think About the Future of Neuroscience.

Ashley V Makela, Jeffrey M Gaudet, Donna H Murrell, James R Mansfield, Max Wintermark, Christopher H Contag

Journal: Neuroscience 2021;474():100-109

PMID: 33197498

Full Text on Elsevier Science View on PubMed

Abstract

Magnetic particle imaging (MPI) is an emerging imaging technique, which has the potential to provide the sensitivity, specificity and temporal resolution necessary for novel imaging advances in neurological applications. MPI relies on the detection of superparamagnetic iron-oxide nanoparticles, which allows for visualization and quantification of iron or iron-labeled cells throughout a subject. The combination of these qualities can be used to image many neurological conditions including cancer, inflammatory processes, vascular-related issues and could even focus on cell therapies and theranostics to treat these problems. This review will provide a basic introduction to MPI, discuss the current use of this technology to image neurological conditions, and touch on future applications including the potential for clinical translation.

Address: Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA. Electronic address: [email protected].; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Magnetic Insight Inc, Alameda, CA, USA.; London Regional Cancer Program, Western University, London, ON, Canada.; Magnetic Insight Inc, Alameda, CA, USA.; Department of Radiology, Stanford University, Stanford, CA, USA.; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.

DOI: 10.1016/j.neuroscience.2020.10.036

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MeSH Terms: Magnetic Phenomena, Magnets, Neurosciences