Unraveling the multifaceted nature of the nuclear function of mTOR.

Alek S Torres, Marina K Holz

Journal: Biochimica et biophysica acta. Molecular cell research 2021;1868(2):118907

PMID: 33189783

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Abstract

Positioned at the axis between the cell and its environment, mTOR directs a wide range of cellular activity in response to nutrients, growth factors, and stress. Our understanding of the role of mTOR is evolving beyond the spatial confines of the cytosol, and its role in the nucleus becoming ever more apparent. In this review, we will address various studies that explore the role of nuclear mTOR (nmTOR) in specific cellular programs and how these pathways influence one another. To understand the emerging roles of nuclear mTOR, we discuss data and propose plausible mechanisms to offer novel ideas, hypotheses, and future research directions.

Address: Department of Biochemistry and Molecular Biology, Graduate School of Basic Medical Sciences, New York Medical College, Valhalla, NY 10595, United States of America.; Department of Cell Biology and Anatomy, Graduate School of Basic Medical Sciences, New York Medical College, Valhalla, NY 10595, United States of America. Electronic address: [email protected].

DOI: 10.1016/j.bbamcr.2020.118907

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https://assays.cancer.gov/CPTAC-1360

MeSH Terms: Cell Nucleus, Humans, TOR Serine-Threonine Kinases