Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections.

Zamaneh Hajikhezri, Mahmoud Darweesh, Göran Akusjärvi, Tanel Punga

Journal: Viruses 2021;12(11):1322

PMID: 33217981

Abstract

The zinc finger proteins make up a significant part of the proteome and perform a huge variety of functions in the cell. The CCCH-type zinc finger proteins have gained attention due to their unusual ability to interact with RNA and thereby control different steps of RNA metabolism. Since virus infections interfere with RNA metabolism, dynamic changes in the CCCH-type zinc finger proteins and virus replication are expected to happen. In the present review, we will discuss how three CCCH-type zinc finger proteins, ZC3H11A, MKRN1, and U2AF1, interfere with human adenovirus replication. We will summarize the functions of these three cellular proteins and focus on their potential pro- or anti-viral activities during a lytic human adenovirus infection.

Address: Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.; Department of Microbiology and Immunology, Al-Azhr University, Assiut 11651, Egypt.

DOI: 10.3390/v12111322

Link outs

Free resources

Full Text Sources:

Miscellaneous:

https://assays.cancer.gov/CPTAC-1020

MeSH Terms: Adenoviridae, Adenovirus Infections, Human, Host Microbial Interactions, Humans, Nerve Tissue Proteins, Nuclear Proteins, RNA-Binding Proteins, Ribonucleoproteins, Splicing Factor U2AF, Virus Replication, Zinc Fingers