Use of Intraoperative Fluorophores.

Alexander J Schupper, Constantinos Hadjipanayis

Journal: Neurosurgery clinics of North America 2021;32(1):55-64

PMID: 33223026

Full Text on Elsevier Science View on PubMed

Abstract

Fluorescence-guided surgery provides surgeons with improved visualization of tumor tissue in the operating room to allow for maximal safe resection of brain tumors. Multiple fluorescent agents have been studied for fluorescence-guided surgery. Both nontargeted and targeted fluorescent agents are currently being used for glioblastoma multiforme visualization and resection. Fluorescence detection in the visible light or near infrared spectrum is possible. Visualization device advancements have permitted greater detection of fluorescence down to the cellular level, which may provide even greater ability for the neurosurgeon to resect tumors.

Address: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY, USA.; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY, USA; Department of Neurosurgery, Mount Sinai Beth Israel, New York, NY, USA. Electronic address: [email protected].

DOI: 10.1016/j.nec.2020.08.001

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MeSH Terms: Brain Neoplasms, Fluorescent Dyes, Glioma, Humans, Neuronavigation, Neurosurgical Procedures