The Crosstalk of Epigenetics and Metabolism in Herpesvirus Infection.

Yonggang Pei, Erle S Robertson

Journal: Viruses 2021;12(12):1377

PMID: 33271926

Abstract

Epigenetics is a versatile player in manipulating viral infection and a potential therapeutic target for the treatment of viral-induced diseases. Both epigenetics and metabolism are crucial in establishing a highly specific transcriptional network, which may promote or suppress virus infection. Human herpesvirus infection can induce a broad range of human malignancies and is largely dependent on the status of cellular epigenetics as well as its related metabolism. However, the crosstalk between epigenetics and metabolism during herpesvirus infection has not been fully explored. Here, we describe how epigenetic regulation of cellular metabolism affects herpesvirus infection and induces viral diseases. This further highlights the importance of epigenetics and metabolism during viral infection and provides novel insights into the development of targeted therapies.

Address: Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, and the Tumor Virology Program, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

DOI: 10.3390/v12121377

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MeSH Terms: Acetyl Coenzyme A, DNA Methylation, Energy Metabolism, Epigenesis, Genetic, Fatty Acids, Flavin-Adenine Dinucleotide, Gene Expression Regulation, Viral, Glutamates, Glycolysis, Herpesviridae, Herpesviridae Infections, Histones, Host-Pathogen Interactions, Humans, NAD