Targeting neuroinflammation: The therapeutic potential of ω-3 PUFAs in substance abuse.

Sha Peng, Zhuang Peng, Meng Qin, Lu Huang, Bin Zhao, Lai Wei, Jie Ning, Qin-Hui Tuo, Ti-Fei Yuan, Zhe Shi, Duan-Fang Liao

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 2021;83():111058

PMID: 33360033

Full Text on Elsevier Science View on PubMed

Abstract

Substance abuse is a chronic relapsing disorder that results in serious health and socioeconomic issues worldwide. Addictive drugs induce long-lasting morphologic and functional changes in brain circuits and account for the formation of compulsive drug-seeking and drug-taking behaviors. Yet, there remains a lack of reliable therapy. In recent years, accumulating evidence indicated that neuroinflammation was implicated in the development of drug addiction. Findings from both our and other laboratories suggest that ω-3 polyunsaturated fatty acids (PUFAs) are effective in treating neuroinflammation-related mental diseases, and indicate that they could exert positive effects in treating drug addiction. Thus, in the present review, we summarized and evaluated recently published articles reporting the neuroinflammation mechanism in drug addiction and the immune regulatory ability of ω-3 PUFAs. We also sought to identify some of the challenges ahead in the translation of ω-3 PUFAs into addiction treatment.

Address: Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Hunan, China.; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China.; Xinxiang Key Laboratory of Forensic Toxicology, School of Forensic Medicine, Xinxiang Medical University, Xinxiang, China.; Department of Metabolic Endocrinology, Shenzhen Longhua District Central Hospital, Shenzhen, China.; Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: [email protected].; Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Hunan, China. Electronic address: [email protected].; Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Hunan, China. Electronic address: [email protected].

DOI: 10.1016/j.nut.2020.111058

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MeSH Terms: Behavior, Addictive, Fatty Acids, Omega-3, Humans, Substance-Related Disorders