Advances in D-Amino Acids in Neurological Research.

James M Seckler, Stephen J Lewis

Journal: International journal of molecular sciences 2021;21(19):7325

PMID: 33023061

Abstract

D-amino acids have been known to exist in the human brain for nearly 40 years, and they continue to be a field of active study to today. This review article aims to give a concise overview of the recent advances in D-amino acid research as they relate to the brain and neurological disorders. This work has largely been focused on modulation of the N-methyl-D-aspartate (NMDA) receptor and its relationship to Alzheimer's disease and Schizophrenia, but there has been a wealth of novel research which has elucidated a novel role for several D-amino acids in altering brain chemistry in a neuroprotective manner. D-amino acids which have no currently known activity in the brain but which have active derivatives will also be reviewed.

Address: Department Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.; Department Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA.

DOI: 10.3390/ijms21197325

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Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/alzheimersdisease.html

Other Literature Sources:

https://bio-protocol.org/e2698

MeSH Terms: Alzheimer Disease, Amino Acids, Brain, Brain Chemistry, Humans, N-Methylaspartate, Receptors, N-Methyl-D-Aspartate, Schizophrenia