Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells.

Simin Sharifi, Solmaz Maleki Dizaj, Farzin Arablouye Moghaddam, Atefeh Abedi, Shahin Ahmadian, Elaheh Dalir Abdolahinia, Seyed Mahdi Hosseiniyan Khatibi, Mohammad Samiei

Journal: BioFactors (Oxford, England) 2021;46(6):874-893

PMID: 33037744

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Abstract

Medicinal plants have always been utilized for the prevention and treatment of the spread of different diseases all around the world. To name some traditional medicine that has been used over centuries, we can refer to phytochemicals such as naringin, icariin, genistein, and resveratrol gained from plants. Osteogenic differentiation and mineralization of stem cells can be the result of specific bioactive compounds from plants. One of the most appealing choices for therapy can be mesenchymal stem cells (MSCs) because it has a great capability of self-renewal and differentiation into three descendants, namely, endoderm, mesoderm, and ectoderm. Stem cell gives us the glad tidings of great advances in tissue regeneration and transplantation field for treatment of diseases. Using plant bioactive phytochemicals also holds tremendous promises in treating diseases such as osteoporosis. The purpose of the present review article thus is to investigate what are the roles and consequences of phytochemicals on osteogenic differentiation of MSCs.

Address: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.; Research Center of Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: 10.1002/biof.1682

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MeSH Terms: Cell Differentiation, Humans, Mesenchymal Stem Cells, Osteogenesis, Phytochemicals