Therapeutic benefits of rutin and its nanoformulations.

Ramin Negahdari, Sepideh Bohlouli, Simin Sharifi, Solmaz Maleki Dizaj, Yalda Rahbar Saadat, Khadijeh Khezri, Samira Jafari, Elham Ahmadian, Negar Gorbani Jahandizi, Safa Raeesi

Journal: Phytotherapy research : PTR 2021;35(4):1719-1738

PMID: 33058407

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Abstract

BACKGROUND

Rutin as a natural flavonoid compound has revealed an extensive range of therapeutic potentials.

PURPOSE

The current paper is focused on the numerous studies on rutin nanoformulations regarding its broad spectrum of therapeutic potentials.

STUDY AND METHODS

A review was conducted in electronic databases (PubMed) to identify relevant published literature in English. No restrictions on publication date were imposed.

RESULTS

The literature search provided 7,078 results for rutin. Among them, 25 papers were related to the potential biological activities of rutin nanoformulations. Polymeric nanoparticles were the most studied nanoformulations for rutin (14 titles) and lipid nanoparticles (5 titles) were in second place. The reviewed literature showed that rutin has been used as an antimicrobial, antifungal, and anti-allergic agent. Improving the bioavailability of rutin using novel drug-delivery methods will help the investigators to use its useful effects in the treatment of various chronic human diseases.

CONCLUSION

It can be concluded that the preparation of rutin nanomaterials for the various therapeutic objects confirmed the enhanced aqueous solubility as well as enhanced efficacy compared to conventional delivery of rutin. However, more investigations should be conducted to confirm the improved bioavailability of the rutin nanoformulations.

Address: Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.; Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.; Student Research Committee, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran, University of Medical Sciences, Sari, Iran.; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: 10.1002/ptr.6904

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MeSH Terms: Humans, Nanoparticles, Rutin