The contribution of uncoupling protein 2 to mitochondrial Ca homeostasis in health and disease - A short revisit.

Zhanat Koshenov, Furkan E Oflaz, Martin Hirtl, Olaf A Bachkoenig, Rene Rost, Karin Osibow, Benjamin Gottschalk, Corina T Madreiter-Sokolowski, Markus Waldeck-Weiermair, Roland Malli, Wolfgang F Graier

Journal: Mitochondrion 2021;55():164-173

PMID: 33069910

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Abstract

Considering the versatile functions attributed to uncoupling protein 2 (UCP2) in health and disease, a profound understanding of the protein's molecular actions under physiological and pathophysiological conditions is indispensable. This review aims to revisit and shed light on the fundamental molecular functions of UCP2 in mitochondria, with particular emphasis on its intricate role in regulating mitochondrial calcium (Ca) uptake. UCP2's modulating effect on various vital processes in mitochondria makes it a crucial regulator of mitochondrial homeostasis in health and disease.

Address: Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria.; Diagnostic and Research Institute for Pathology, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria; Department of Health Sciences and Technology, ETH Zurich, Schorenstraße 16, 8603 Schwerzenbach, Switzerland.; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria; Diagnostic and Research Institute for Pathology, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria; BioTechMed, Graz, Austria.; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria; BioTechMed, Graz, Austria. Electronic address: [email protected].

DOI: 10.1016/j.mito.2020.10.003

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1567...

Medical:

https://medlineplus.gov/mitochondrialdiseases.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-177

MeSH Terms: Calcium, HeLa Cells, Homeostasis, Humans, Mitochondria, Mitochondrial Diseases, Uncoupling Protein 2