Periviable Premature Rupture of Membranes.

Kelly S Gibson, Kerri Brackney

Journal: Obstetrics and gynecology clinics of North America 2021;47(4):633-651

PMID: 33121650

Full Text on Elsevier Science View on PubMed

Abstract

Periviable deliveries (less than 26 weeks) are a small percentage of deliveries but account for a disproportionately high number of long-term morbidities. Few studies describe interventions and outcomes for periviable preterm premature rupture of membranes (PPROM). The available reports may include only those neonates who received resuscitation, making interpretation and application difficult. Counseling should consider the impact of oligohydramnios on fetal lung development. This article discusses standard and experimental interventions that may offer neonatal benefit. Antenatal corticosteroids, antibiotics, and magnesium sulfate may improve outcomes but data to support an improvement in outcome are limited. Studies specifically evaluating these interventions are needed.

Address: Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Case Western Reserve University, The MetroHealth System, Suite G240, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA. Electronic address: [email protected].; Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Case Western Reserve University, The MetroHealth System, Suite G240, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA.

DOI: 10.1016/j.ogc.2020.08.007

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MeSH Terms: Adrenal Cortex Hormones, Amniotic Fluid, Anti-Bacterial Agents, Bronchopulmonary Dysplasia, Cerclage, Cervical, Chorioamnionitis, Female, Fetal Membranes, Premature Rupture, Fetal Viability, Gestational Age, Humans, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Magnesium Sulfate, Pregnancy, Pregnancy Outcome, Premature Birth