Bone Health in Childhood Chronic Disease.

David R Weber

Journal: Endocrinology and metabolism clinics of North America 2021;49(4):637-650

PMID: 33153671

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Abstract

Many children with chronic disease are now surviving into adulthood. As a result, there is a growing interest in optimizing bone health early in the disease course with the dual goals of improving quality of life during childhood and reducing life-long fracture risk. Risk factors for impaired bone health in these children include immobility, nutritional deficiency, exposure to bone toxic therapies, hormonal deficiencies affecting growth and pubertal development, and chronic inflammation. This review focuses on the chronic diseases of childhood most commonly associated with impaired bone health. Recent research findings and clinical practice recommendations, when available, for specific disorders are summarized.

Address: Department of Pediatrics - Endocrinology, Golisano Children's Hospital, University of Rochester, Rochester, NY, USA. Electronic address: [email protected].

DOI: 10.1016/j.ecl.2020.07.002

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MeSH Terms: Bone Density Conservation Agents, Bone Diseases, Child, Chronic Disease, Diphosphonates, Humans, Inflammation, Malnutrition, Mobility Limitation