Effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.

Zatollah Asemi, Omid Reza Tamtaji, Alireza Milajerdi, Željko Reiner, Ehsan Dadgostar, Elaheh Amirani, Liaosadat Mirsafaei, Mohammad Ali Mansournia, Parisa Maleki Dana, Fatemeh Sadoughi, Jamal Hallajzadeh

Journal: Clinical nutrition ESPEN 2021;40():27-33

PMID: 33183549

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVE

This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to analyze the effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome (MetS) and related disorders.

METHODS

Databases including PubMed, Scopus, EMBASE, Web of Science, and Cochrane Central library were searched until January 31, 2019.

RESULTS

14 effect sizes from 12 studies were identified eligible to be included in current meta-analysis. Flaxseed supplementation resulted in a significant reduction in interleukin 6 (IL-6) (WMD: -0.22; 95% CI: -0.43, -0.01) and malondialdehyde (MDA) (WMD: -0.17; 95% CI: -0.31, -0.03) and a significant increase in total antioxidant capacity (TAC) levels (WMD: 137.25; 95% CI: 68.04, 206.47). Flaxseed oil supplementation did not affect other biomarkers of inflammation and oxidative stress.

CONCLUSIONS

Overall, this meta-analysis demonstrated flaxseed oil supplementation decreased IL-6 and MDA levels, and increased TAC, but did not affect other biomarkers of inflammation and oxidative stress among patients with MetS and related disorders. This suggests that flaxseed oil supplementation may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders.

Address: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. Electronic address: [email protected].; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. Electronic address: [email protected].; Halal Research Center of IRI, FDA, Tehran, Iran. Electronic address: [email protected].; Department of Cardiology, Ramsar Campus, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. Electronic address: [email protected].; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.clnesp.2020.09.017

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MeSH Terms: Biomarkers, Dietary Supplements, Humans, Inflammation, Linseed Oil, Metabolic Syndrome, Oxidative Stress, Randomized Controlled Trials as Topic