Effects of Nutrition/Diet on Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis.

Kelsey A Heenan, Andres E Carrillo, Jacob L Fulton, Edward J Ryan, Jason R Edsall, Dimitrios Rigopoulos, Melissa M Markofski, Andreas D Flouris, Petros C Dinas

Journal: Nutrients 2021;12(9):2752

PMID: 32927664

Free Full Text on MDPI View on PubMed

Plain Language Summary

The body has many uses for the energy that is consumed in the diet, one of these is for the generation of heat. Brown adipose tissue (BAT), which is stored in the lower neck, collarbone, abdomen and along the spine, is a special type of fat that is activated when the body is cold and serves to generate heat. The activity of this fat is of benefit to humans, as it reduces weight gain, improves blood sugar balance, and helps reduce blood lipid levels, reducing the risk for heart disease and type 2 diabetes. This systematic review of 24 publications aimed to determine whether nutrition and/or diet affects the activity of BAT. The results showed that there was no change in BAT activity following a high calorie carbohydrate rich meal, a standard meal and during overfeeding. Supplementation of L-Arginine, which is a supplement that helps the body build muscle, also had no effect on BAT activity. It was concluded that BAT activity was not affected by nutrition or diet. This study could be used by healthcare professionals to understand that the effect of diet on risk for heart disease and type 2 diabetes may not involve the modification of BAT.

Abstract

BACKGROUND

Brown adipose tissue (BAT) provides a minor contribution to diet-induced thermogenesis (DIT)-the metabolic response to food consumption. Increased BAT activity is generally considered beneficial for mammalian metabolism and has been associated with favorable health outcomes. The aim of the current systematic review was to explore whether nutritional factors and/or diet affect human BAT activity.

METHODS

We searched PubMed Central, Embase and Cochrane Library (trials) to conduct this systematic review (PROSPERO protocol: CRD42018082323).

RESULTS

We included 24 eligible papers that studied a total of 2785 participants. We found no mean differences in standardized uptake value of BAT following a single meal or after 6 weeks of L-Arginine supplementation. Resting energy expenditure (REE), however, was increased following a single meal and after supplementation of capsinoid and catechin when compared to a control condition (Z = 2.41, = 0.02; mean difference = 102.47 (95% CI = 19.28-185.67)).

CONCLUSIONS

Human BAT activity was not significantly affected by nutrition/diet. Moreover, REE was only increased in response to a single meal, but it is unlikely that this was due to increased BAT activity. BAT activity assessments in response to the chronic effect of food should be considered along with other factors such as body composition and/or environmental temperature.

Address: Department of Movement Science, Chatham University, Pittsburgh, PA 15232, USA.; FAME Laboratory, Department of Exercise Science, University of Thessaly, GR42100 Trikala, Greece.; Department of Health and Human Performance, University of Houston, Houston, TX 77204, USA.

DOI: 10.3390/nu12092752