To resist and persist: Important factors in the pathogenesis of Bacteroides fragilis.

Mina Yekani, Hossein Bannazadeh Baghi, Behrooz Naghili, Sepideh Zununi Vahed, József Sóki, Mohammad Yousef Memar

Journal: Microbial pathogenesis 2021;149():104506

PMID: 32950639

Full Text on Elsevier Science View on PubMed

Abstract

Bacteroides fragilis is a most frequent anaerobic pathogen isolated from human infections, particularly found in the abdominal cavity. Different factors contribute to the pathogenesis and persistence of B. fragilis at infection sites. The knowledge of the virulence factors can provide applicable information for finding alternative options for the antibiotic therapy and treatment of B. fragilis caused infections. Herein, a comprehensive review of the important B. fragilis virulence factors was prepared. In addition to B. fragilis toxin (BFT) and its potential role in the diarrhea and cancer development, some other important virulence factors and characteristics of B. fragilis are described including capsular polysaccharides, iron acquisition, resistance to antimicrobial agents, and survival during the prolonged oxidative stress, quorum sensing, and secretion systems.

Address: Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Student Research Committee,Kashan University of Medical Sciences, Kashan, Iran.; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary. Electronic address: [email protected].; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: [email protected].

DOI: 10.1016/j.micpath.2020.104506

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MeSH Terms: Anti-Bacterial Agents, Bacterial Infections, Bacteroides Infections, Bacteroides fragilis, Humans, Virulence Factors