Medicinal Potential of Species and Their Compounds.

Bruna Larissa Spontoni do Espirito Santo, Lidiani Figueiredo Santana, Wilson Hino Kato Junior, Felipe de Oliveira de Araújo, Danielle Bogo, Karine de Cássia Freitas, Rita de Cássia Avellaneda Guimarães, Priscila Aiko Hiane, Arnildo Pott, Wander Fernando de Oliveira Filiú, Marcel Arakaki Asato, Patrícia de Oliveira Figueiredo, Paulo Roberto Haidamus de Oliveira Bastos

Journal: Molecules (Basel, Switzerland) 2021;25(19):4513

PMID: 33019745

Abstract

is a genus of Clusiaceae, distributed throughout tropical Asia, Africa, New Caledonia, Polynesia, and Brazil. plants contain a broad range of biologically active metabolites which, in the last few decades, have received considerable attention due to the chemical compositions of their extracts, with compounds which have been shown to have beneficial effects in several diseases. Our work had the objective of reviewing the benefits of five species (, , , , and ). These species provide a rich natural source of bioactive compounds with relevant therapeutic properties and anti-inflammatory effects, such as for the treatment of skin disorders, wounds, pain, and infections, having demonstrated antinociceptive, antioxidant, antitumoral, antifungal, anticancer, antihistaminic, antiulcerogenic, antimicrobial, antiviral, vasodilator, hypolipidemic, hepatoprotective, nephroprotective, and cardioprotective properties. This demonstrates the relevance of the genus as a rich source of compounds with valuable therapeutic properties, with potential use in the prevention and treatment of nontransmissible chronic diseases.

Address: Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, 79070-900 Campo Grande, Brazil.; Graduate of Pharmaceutical Sciences, Federal University of Mato Grosso do Sul-UFMS, 79070-900 Campo Grande, Brazil.; Graduate of Electrical Engineering, Federal University of Mato Grosso do Sul-UFMS, 79070-900 Campo Grande, Brazil.; Laboratory of Botany, Institute of Biosciences, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, Brazil.; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul-UFMS, 79070-900 Campo Grande, Brazil.; Medical School, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, Brazil.; Laboratory PRONABio (Bioactive Natural Products)-Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, 79074-460 Campo Grande, Brazil.
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