Effects of chamomile extract nasal drop on chronic rhinosinusitis treatment: A randomized double blind study.

Shadman Nemati, Fatemeh Yousefbeyk, Seyedeh Matin Ebrahimi, Ali Faghih FaghihHabibi, Maryam Shakiba, Hedieh Ramezani

Journal: American journal of otolaryngology 2021;42(1):102743

PMID: 33038782

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVES

Recently, more attention has been paid to herbal treatment in chronic rhinosinusitis (CRS) patients. Chamomile (Matrricaria chamomilla) has extensive clinical uses in traditional-Persian medicine for its therapeutic properties. This study aimed to evaluate the effects of chamomile extract on the clinical symptoms of patients with CRS in a university hospital.

MATERIALS AND METHODS

In a randomized double-blind placebo-group clinical trial, 74 CRS patients were examined by an otolaryngologist blinded to the study groups, and the effects of treatment (according to SNOT-22 questionnaire) and possible complications recorded. Statistical analysis performed using SPSS software version 21, and level of significance considered as P < 0.05.

RESULTS

Of the 74 patients (31 females and 43 male), 37 cases randomized in the intervention and 37 cases in the placebo group. The Lund-Mackay score, clinical findings in endoscopic nasal examination and mean score of the SNOT-22 were not significantly different at baseline visit between the two study groups. The adjusted mean score of quality of life during the four time periods in the intervention group (34.3, confidence interval of 95%: 31.8-36.7) was significantly lower than that of control group (45.9, confidence interval of 95%: 43.5-48.4) (P-value = 0.001). Also, clinical improvement in endoscopic nasal examination was significant in intervention group compared with placebo group.

CONCLUSION

Chamomile extract is effective in further reducing the clinical symptoms and improving the quality of life of CRS patients.

Address: Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.; Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.; Otorhinolaryngology Research Center, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.; Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: [email protected].; Cardiovascular Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

DOI: 10.1016/j.amjoto.2020.102743

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MeSH Terms: Administration, Intranasal, Adult, Chamomile, Chronic Disease, Double-Blind Method, Female, Humans, Male, Middle Aged, Phytotherapy, Plant Extracts, Quality of Life, Rhinitis, Sinusitis, Treatment Outcome