Bioresorbable Coronary Scaffold Technologies: What's New?

Giulia Masiero, Giulio Rodinò, Juji Matsuda, Giuseppe Tarantini

Journal: Cardiology clinics 2021;38(4):589-599

PMID: 33036720

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Abstract

To overcome the not negligible metallic drug-eluting stents adverse events rate, the polymeric or metallic bioresorbable scaffolds were designed to provide early drug delivery and mechanical support followed by complete resorption. However, the long-term evidence, focusing on the leading Absorb BVS technology, showed higher events compared with drug-eluting stents. This review discusses the lights and shadows of the current bioresorbable scaffolds according to their mechanical properties and biodegradation profile and suggests possible perspective on these technologies. Improved scaffold design and deployment techniques might mitigate early bioresorbable scaffolds risk enhancing the late benefit of complete resorption.

Address: Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Via Giustiniani 2, Padua 35128, Italy. Electronic address: [email protected].; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Via Giustiniani 2, Padua 35128, Italy.; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Via Giustiniani 2, Padua 35128, Italy; Department of Cardiovascular Medicine, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113 - 8510, Japan.

DOI: 10.1016/j.ccl.2020.07.004

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MeSH Terms: Absorbable Implants, Coronary Artery Disease, Drug-Eluting Stents, Equipment Failure, Humans, Magnesium, Polyesters, Prosthesis Design