Manganese Exposure and Neurologic Outcomes in Adult Populations.

Kaitlin V Martin, David Edmondson, Kim M Cecil, Cassandra Bezi, Miriam Leahshea Vance, Dani McBride, Erin N Haynes

Journal: Neurologic clinics 2021;38(4):913-936

PMID: 33040869

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Abstract

A review of published articles examining the effects of manganese exposure to workers and community residents shows adverse neurologic outcomes. Innovative biomarkers, including those from neuroimaging, were incorporated into many of these studies to assess both manganese exposure and neurologic outcomes. A variety of health effects were evaluated, including cognitive and motor impairments. Studies of community participants residing near manganese point sources show variability in outcomes, reflecting the complexities of exposure measurement, individual absorption, and assessment of neurologic effects. The aging population provides insight into the impacts of chronic exposure in younger populations.

Address: Department of Epidemiology, College of Public Health, University of Kentucky, 111 Washington Avenue Room 212C, Lexington, KY 40536, USA. Electronic address: [email protected].; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Imaging Research Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5033, Cincinnati, OH 45229, USA.; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Imaging Research Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5033, Cincinnati, OH 45229, USA; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7017, Cincinnati, OH 45229, USA.; Department of Epidemiology, College of Public Health, University of Kentucky, 111 Washington Avenue, Lexington, KY 40536, USA.; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.; Department of Epidemiology, College of Public Health, University of Kentucky, 111 Washington Avenue Room 212G, Lexington, KY 40536, USA.

DOI: 10.1016/j.ncl.2020.07.008

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MeSH Terms: Aged, Humans, Manganese, Middle Aged, Neurotoxicity Syndromes