Hypermethylated promoters of genes and as potential novel diagnostic biomarkers in colorectal cancer.

Sara Uhan, Nina Zidar, Aleš Tomažič, Nina Hauptman

Journal: Epigenomics 2021;12(19):1677-1688

PMID: 33078631

Abstract

Identification of aberrant hypermethylation in promoter regions of candidate genes to discover potential biomarkers for colorectal cancer. Genes , , , , , and were pre-selected in a bioinformatics study for their hypermethylation status in colorectal cancer. Methylation analysis was performed on 202 cancer tissue specimens to validate candidate genes. Genes and displayed methylation in 95.3 and 99.7% of The Cancer Genome Atlas dataset samples and in 96 and 98% of our experimentally tested samples, respectively. and promoter hypermethylation holds diagnostic biomarker potential in patients with early colorectal cancer.

Address: Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.; Department of Abdominal Surgery, University Medical Center Ljubljana, Zaloška cesta 2, 1000 Ljubljana, Slovenia.

DOI: 10.2217/epi-2020-0118

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https://www.tandfonline.com/doi/10.2217/epi-2020-0...

Medical:

https://medlineplus.gov/colorectalcancer.html

Molecular Biology Databases:

https://glygen.org/publication/PubMed/33078631/

MeSH Terms: Adult, Aged, Aged, 80 and over, Biomarkers, Colorectal Neoplasms, DNA Methylation, Female, Humans, Kv1.1 Potassium Channel, Male, Middle Aged, Promoter Regions, Genetic, Receptors, Cell Surface