Calcium signaling modulates the dynamics of cilia and flagella.

M V Satarić, S Zdravković, T Nemeš, B M Satarić

Journal: European biophysics journal : EBJ 2021;49(7):619-631

PMID: 33105487

Abstract

To adapt to changing environments cells must signal and signaling requires messengers whose concentration varies with time in space. We here consider the messenger role of calcium ions implicated in regulation of the wave-like bending dynamics of cilia and flagella. The emphasis is on microtubules as polyelectrolytes serving as transmission lines for the flow of Ca signals in the axoneme. This signaling is superimposed with a geometric clutch mechanism for the regulation of flagella bending dynamics and our modeling produces results in agreement with experimental data.

Address: Serbian Academy of Science and Arts, Belgrade, Serbia.; Vinča Institute for Nuclear Sciences, University of Belgrade, Belgrade, Serbia.; Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia. [email protected].; Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia.

DOI: 10.1007/s00249-020-01471-8

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https://dx.doi.org/10.1007/s00249-020-01471-8

MeSH Terms: Axoneme, Calcium, Calcium Signaling, Chlamydomonas, Cilia, Flagella, Ions, Microtubules, Models, Biological, Molecular Conformation, Polyelectrolytes