Microvascular angiogenesis and the renin-angiotensin system.

Andrew S Greene, Sandra L Amaral

Journal: Current hypertension reports 2002;4(1):56-62

PMID: 11790293

Abstract

The renin-angiotensin system is one of the major regulatory mechanisms essential for maintaining cardiovascular homeostasis. Angiotensin II is a multifunctional hormone that plays a key role in regulating this system. The importance of the renin-angiotensin system in controlling sodium homeostasis and vascular resistance is well established, however, in the past decade, much attention has been focused on the importance of angiotensin II as a regulator of microvessel density, acting through the AT1 and AT2 receptors. In this review, we discuss the connections between the renin-angiotensin system and other growth factor pathways known to be involved in pathologic and physiologic angiogenesis and rarefaction.

Address: Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI, 53226, USA. [email protected]

DOI: 10.1007/s11906-002-0054-x

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MeSH Terms: Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Captopril, Endothelial Growth Factors, Heart, Homeostasis, Humans, Lymphokines, Neovascularization, Physiologic, Receptor, Angiotensin, Type 1, Receptors, Angiotensin, Renin-Angiotensin System, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors