Eosinophilic esophagitis: updates on key unanswered questions.

Nielsen Q Fernandez-Becker, Shreya Raja, Carmelo Scarpignato, Kristle L Lynch, Nitin K Ahuja, Jennifer L Horsley-Silva

Journal: Annals of the New York Academy of Sciences 2020;1481(1):30-42

PMID: 32762154

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

Eosinophilic esophagitis (EoE) is a clinicopathologic disease characterized by symptoms of esophageal dysfunction and esophageal eosinophilia. In the last decade, there has been a dramatic increase in its prevalence for reasons that are not completely understood. The underlying pathophysiology involves an antigen-mediated T 2 immune response that draws eosinophils to the esophagus, causing mucosal inflammation, esophageal remodeling, and fibrosis. This ultimately leads to esophageal dysfunction that most commonly manifests as dysphagia. In this review, we will discuss updates on key questions regarding the diagnosis and treatment of EoE.

Address: Department of Medicine, Stanford University, Redwood City, California.; Department of Medicine, Emory University, Atlanta, Georgia.; Department of Health Sciences, United Campus of Malta, Msida, Malta.; Faculty of Medicine, Chinese University of Hong Kong, Sha Tin, Hong Kong.; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Medicine, The Mayo Clinic, Scottsdale, Arizona.

DOI: 10.1111/nyas.14421

Link outs

Free resources

Medical:

https://medlineplus.gov/swallowingdisorders.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Deglutition Disorders, Eosinophilic Esophagitis, Eosinophils, Esophagus, Humans, Inflammation, Th2 Cells