Intractable Ocular Diseases and Treatment Progress.

Xinru Zhang, Shuhan Li, Yue Tang, Yuzun Guo, Shuai Gao

Journal: AAPS PharmSciTech 2020;21(6):236

PMID: 32803351

Abstract

In recent years, with the aging of the population and the frequent use of electronic devices, many eye diseases have shown a linear upward trend, such as dry eye disease, glaucoma, cataract, age-related macular degeneration, and diabetic retinopathy. These diseases are often chronic and difficult to cure. Based on the structure and barrier of the human eye, this review describes the pathogenesis and treatments of several intractable eye diseases and summarizes the advanced ocular drug delivery systems to provide new treatment ideas for these diseases. Finally, we also look forward to the prospect of RNAi therapy in the treatment of eye diseases.

Address: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, No.1, DongQing Road, Guiyang, 550014, People's Republic of China.; Department of Pharmacy, China Pharmaceutical University, No.639, Longmian Avenue, Nanjing, 211198, People's Republic of China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, No.1, DongQing Road, Guiyang, 550014, People's Republic of China. [email protected].; Department of Pharmacy, China Pharmaceutical University, No.639, Longmian Avenue, Nanjing, 211198, People's Republic of China. [email protected].

DOI: 10.1208/s12249-020-01774-1

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https://dx.doi.org/10.1208/s12249-020-01774-1

MeSH Terms: Adrenergic beta-Antagonists, Antihypertensive Agents, Cataract, Diabetic Retinopathy, Drug Delivery Systems, Dry Eye Syndromes, Eye Diseases, Glaucoma, Humans, Latanoprost, Macular Degeneration, Photosensitizing Agents, Timolol, Treatment Outcome, Verteporfin