Emerging New Diagnostic Modalities and Therapies of Nonalcoholic Fatty Liver Disease.

Chuan-Hao Lin, Rohit Kohli

Journal: Current gastroenterology reports 2021;22(10):52

PMID: 32814993

Abstract

PURPOSE OF REVIEW

Nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease in both adults and children. In this article, we review recent developments in the screening, diagnosis, and treatment of pediatric NAFLD.

RECENT FINDINGS

Although alanine aminotransferase (ALT) remains the best screening test for NAFLD in children, and liver biopsy is still required for the diagnosis of nonalcoholic steatohepatitis (NASH), other noninvasive biomarker/imaging studies (MRI-PDFF and VCTE) have emerged as diagnostic methods for pediatric NAFLD. Two large clinical therapeutic trials testing vitamin E, metformin, and cysteamine in pediatric NAFLD yielded mostly inconclusive results. Bariatric surgery has begun to be used in adolescents with severe obesity. An adult phase 2 study using obeticholic acid (OCA) to treat NASH patients with fibrosis showed some positive results. As we continue to await the first FDA-approved therapeutic agent for NASH, lifestyle change remains the main modality of treatment. Newer diagnostic and treatment modalities for pediatric NAFLD continue to be in development under FDA guidance.

Address: Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, and the Department of Pediatrics, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Mail Stop 78, Los Angeles, CA, 90027, USA. [email protected].; Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, and the Department of Pediatrics, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Mail Stop 78, Los Angeles, CA, 90027, USA.

DOI: 10.1007/s11894-020-00786-y

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Full Text Sources:

https://dx.doi.org/10.1007/s11894-020-00786-y

MeSH Terms: Adolescent, Alanine Transaminase, Antioxidants, Bariatric Surgery, Child, Child, Preschool, Cysteamine, Cystine Depleting Agents, Delayed-Action Preparations, Diet, Humans, Hypoglycemic Agents, Infant, Infant, Newborn, Life Style, Liver Cirrhosis, Metformin, Non-alcoholic Fatty Liver Disease, Pediatric Obesity, Vitamin E