TRPC6 channel and its implications in breast cancer: an overview.

Gines M Salido, Juan A Rosado, Isaac Jardin, Joel Nieto

Journal: Biochimica et biophysica acta. Molecular cell research 2021;1867(12):118828

PMID: 32822726

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Abstract

TRPC6 channel is widely expressed in most human tissues and participates in a number of physiological processes. TRPC6 belongs to the DAG-activated subfamily of channels, but has also been postulated as a mediator in the store-operated calcium entry pathway. The recent characterization of TRPC6 crystal structure has granted a wonderful tool to finally dissect and understand TRPC6 physiological and biophysical properties. Growing evidences have demonstrated that the pattern of expression of TRPC6 proteins is upregulated in several pathophysiological conditions, including breast cancer. However, the real role of TRPC6 in breast cancer persists still unknown. Here we present the current state of the art concerning the function and significance of TRPC6 in this disease. Future investigations should be focus in the creation and identification of compounds that specifically target the channel to ameliorate TRPC6-related diseases.

Address: Cellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain. Electronic address: [email protected].; Cellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.

DOI: 10.1016/j.bbamcr.2020.118828

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0167...

Medical:

https://medlineplus.gov/breastcancer.html

MeSH Terms: Breast Neoplasms, Calcium, Female, Gene Expression Regulation, Neoplastic, Humans, Ion Transport, TRPC6 Cation Channel