SLC16 Family: From Atomic Structure to Human Disease.

Patrick D Bosshart, Roch-Philippe Charles, Rachel-Ann A Garibsingh, Avner Schlessinger, Dimitrios Fotiadis

Journal: Trends in biochemical sciences 2021;46(1):28-40

PMID: 32828650

Full Text on Elsevier Science View on PubMed

Abstract

The solute carrier 16 (SLC16) family represents a diverse group of membrane proteins mediating the transport of monocarboxylates across biological membranes. Family members show a variety of functional roles ranging from nutrient transport and intracellular pH regulation to thyroid hormone homeostasis. Changes in the expression levels and transport function of certain SLC16 transporters are manifested in severe health disorders including cancer, diabetes, and neurological disorders. L-Lactate-transporting SLC16 family members play essential roles in the metabolism of certain tumors and became validated drug targets. This review illuminates the SLC16 family under a new light using structural information obtained from a SLC16 homolog. Furthermore, the role of these transporters in cancer metabolism and how their inhibition can contribute to anticancer therapy are discussed.

Address: Institute of Biochemistry and Molecular Medicine and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, CH-3012 Bern, Switzerland.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute of Biochemistry and Molecular Medicine and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, CH-3012 Bern, Switzerland. Electronic address: [email protected].

DOI: 10.1016/j.tibs.2020.07.005

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MeSH Terms: Biological Transport, Humans, Monocarboxylic Acid Transporters, Protein Conformation, Symporters, X-Ray Diffraction