Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation.

Masato Kobayashi, Mei Harada, Hideo Takakura, Kanta Ando, Yuto Goto, Mikako Ogawa, Tetsuya Taketsugu, Takao Tsuneda

Journal: ChemPlusChem 2021;85(9):1953

PMID: 32830450

Abstract

Invited for this month's cover are the collaborating groups of Dr. Masato Kobayashi and Prof. Mikako Ogawa, both from Hokkaido University, Sapporo, Japan. The cover picture shows the photochemical reaction process of the near-infrared (NIR) photoimmunotherapy dye IR700, and subsequent cancer cell death. A computational study predicted that ligand dissociation, which is known to initiate cancer cell death, proceeds by the hydrolysis of the IR700 radical anion, rather than as a direct result of NIR irradiation. This mechanism has also been supported by experimental work. Read the full text of the Communication at 10.1002/cplu.202000338.

Address: Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.; WPI-ICReDD, Hokkaido University, Sapporo, 001-0021, Japan.; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.; Graduate School of Science, Technology, and Innovation, Kobe University, Kobe, 657-8501, Japan.

DOI: 10.1002/cplu.202000502

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https://doi.org/10.1002/cplu.202000502

MeSH Terms: Anions, Humans, Hydrolysis, Immunotherapy, Indoles, Infrared Rays, Models, Theoretical, Organosilicon Compounds, Photosensitizing Agents, Phototherapy