Biosynthesis and attachment of novel bacterial polyketide synthase starter units.

Bradley S Moore, Christian Hertweck

Journal: Natural product reports 2002;19(1):70-99

PMID: 11902441

Full Text on Royal Society of Chemistry View on PubMed

Abstract

The biosynthesis and mode of attachment of a wide range of polyketide synthase (PKS) starter units in bacteria are covered in this review. Natural, unnatural, and engineered starter units associated with type I and type II PKSs are reported. The literature through early 2001 is reviewed, and 240 references cited.

Address: Division of Medicinal Chemistry, College of Pharmacy, University of Arizona, Tucson 85721-0207, USA. [email protected]

DOI: 10.1039/b003939j

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https://doi.org/10.1039/b003939j

MeSH Terms: Amino Acids, Anti-Bacterial Agents, Bacteria, Bridged-Ring Compounds, Butyrates, Catalysis, Erythromycin, Ivermectin, Molecular Structure, Multienzyme Complexes, Peptides, Polyenes, Polyunsaturated Alkamides, Propionates, Rifabutin, Rifamycins, Salicylates