Rethinking gastroesophageal reflux disorder.

Samuel P Banting, Henry E Badgery, Matthew Read, Hiroshi Mashimo

Journal: Annals of the New York Academy of Sciences 2021;1482(1):177-192

PMID: 32875572

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Abstract

Gastroesophageal reflux disease (GERD) is a common clinical condition for which our understanding has evolved over the past decades. It is now considered a cluster of phenotypes with numerous anatomical and physiological abnormalities contributing to its pathophysiology. As such, it is important to first understand the underlying mechanism of the disease process for each patient before embarking on therapeutic interventions. The aim of our paper is to highlight the mechanisms contributing to GERD and review investigations and interpretation of these results. Finally, the paper reviews the available treatment modalities for this condition, ranging from medical intervention, endoscopic options through to surgery and its various techniques.

Address: Department of General Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Upper Gastrointestinal Surgery, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.; Department of Surgery, the University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.; Department of Medicine, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts.

DOI: 10.1111/nyas.14478

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MeSH Terms: Barrett Esophagus, Esophageal Sphincter, Lower, Esophagogastric Junction, Esophagoscopy, Fundoplication, Gastroesophageal Reflux, Hernia, Hiatal, Humans, Life Style, Manometry, Obesity, Proton Pump Inhibitors