Archaeal hyperthermostable mannitol dehydrogenases: A promising industrial enzymes for d-mannitol synthesis.

Marwa Yagoub Farag Koko, Wanmeng Mu, Hinawi Abdo Mustafa Hassanin, Shuang Zhang, Han Lu, Jalaleldeen Khaleel Mohammed, Muhammad Hussain, Qi Baokun, Li Yang

Journal: Food research international (Ottawa, Ont.) 2021;137():109638

PMID: 33233217

Full Text on Elsevier Science View on PubMed

Abstract

Recently, the term healthy lifestyle connected to low-calorie diets, although it is not possible to get rid of added sugars as a source of energy, despite the close relation of added sugars to some diseases such as obesity, diabetes, etc. As a result, the sweetener market has flourished, which has led to increased demand for natural sweeteners such as polyols, including d-mannitol. Various methods have been developed to produce d-mannitol to achieve high productivity and low cost. In particular, metabolic engineering for d-mannitol considers one of the most promising approaches for d-mannitol production on the industrial scale. To date, the chemical process is not ideal for large-scale production because of its multistep mechanism involving hydrogenation and high cost. In this review, we highlight and present a comparative evaluation of the biochemical parameters that affecting d-mannitol synthesis from Thermotoga neapolitana and Thermotoga maritima mannitol dehydrogenase (MtDH) as a potential contribution for d-mannitol bio-synthesis. These species were selected because purified mannitol dehydrogenases from both strains have been reported to produce d-mannitol with no sorbitol formation under temperatures (90-120 °C).

Address: Department of Food, Grease and Vegetable Protein Engineering, School of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.; Department of Food, Grease and Vegetable Protein Engineering, School of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address: [email protected].; Department of Food, Grease and Vegetable Protein Engineering, School of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address: [email protected].

DOI: 10.1016/j.foodres.2020.109638

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MeSH Terms: Archaea, Carbohydrate Metabolism, Mannitol, Mannitol Dehydrogenases, Sweetening Agents