When non-coding is not enough.

Simone Anfossi, George A Calin

Journal: The Journal of experimental medicine 2020;217(3):e20192009

PMID: 32023341

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Abstract

A new concept is emerging in the non-coding RNA (ncRNA) field: an increasing number of ncRNAs in fact codify for short peptides that have biological activities. In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20190950) report the identification of a long ncRNA (lncRNA)-encoded 60-amino acid polypeptide that they name ASRPS, as well as its ability to inhibit angiogenesis in the deadly triple-negative breast cancer (TNBC).

Address: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX.

DOI: 10.1084/jem.20192009

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MeSH Terms: Humans, MicroRNAs, Peptides, RNA, Long Noncoding, RNA, Untranslated, Triple Negative Breast Neoplasms