Intravenous Migraine Treatment in Children and Adolescents.

Klaus Werner, Sharoon Qaiser, Marielle Kabbouche, Beverly Murphy, Ian Maconochie, Andrew D Hershey

Journal: Current pain and headache reports 2021;24(8):45

PMID: 32638172

Abstract

[{"label":"PURPOSE OF REVIEW","text":"Pediatric migraine is a common, chronic, and disabling neurological disorder in children and adolescents. Outpatient management is not always effective, and intravenous migraine management may be necessary for headache treatment in the pediatric emergency department. Most current treatment is based on retrospective evidence and there is a lack of well-designed randomized double-blinded controlled pediatric studies. Intravenous drug treatment agents including intravenous fluids, prochlorperazine, diphenhydramine, metoclopramide, dexamethasone, magnesium, valproate and propofol, and dihydroergotamine are reviewed in this paper."},{"label":"RECENT FINDINGS","text":"Nineteen studies were reviewed including one prospective randomized double-blind; one single-blinded randomized; one prospective; and one open-label, randomized clinical trial. Most studies were retrospective and the quality of the studies was limited. No definite conclusions can be drawn from the studies, but appropriate prospective trials between major pediatric headache institutions will move pediatric intravenous migraine management forward."}]

Address: Division of Pediatric Neurology, Duke University Medical Center, Durham, NC, USA. [email protected].; Department of Neurology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, E4-310, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.; Medical Center Library & Archives, Duke University Medical Center, Durham, NC, 27710, USA.; Imperial College Healthcare NHS Trust, London, UK.

DOI: 10.1007/s11916-020-00867-7

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https://medlineplus.gov/migraine.html

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Full Text Sources:

https://dx.doi.org/10.1007/s11916-020-00867-7

MeSH Terms: Administration, Intravenous, Adolescent, Akathisia, Drug-Induced, Anesthetics, Local, Anti-Inflammatory Agents, Non-Steroidal, Antibodies, Monoclonal, Humanized, Basal Ganglia Diseases, Child, Dexamethasone, Dihydroergotamine, Diphenhydramine, Dopamine Antagonists, Emergency Service, Hospital, Enzyme Inhibitors, Fluid Therapy, Glucocorticoids, Hospitalization, Humans, Hypnotics and Sedatives, Ketorolac, Lidocaine, Magnesium, Migraine Disorders, Prochlorperazine, Propofol, Valproic Acid, Vasoconstrictor Agents