Rheological properties of synovial fluid due to viscosupplements: A review for osteoarthritis remedy.

S More, A Kotiya, A Kotia, S K Ghosh, L A Spyrou, I E Sarris

Journal: Computer methods and programs in biomedicine 2021;196():105644

PMID: 32645531

Full Text on Elsevier Science View on PubMed

Abstract

The synovial fluid is a transparent electrolyte solution included in joints to provide lubrication helping the proper movement. It exhibits complex rheological properties due to the interaction among its constituents i.e. hyaluronic acid, albumin, lubricin and phospholipids. In degenerative osteoarthritis and inflammatory rheumatoid arthritis diseases, the quantity of synovial fluid and lubrication efficiency significantly deteriorates. In that case, viscosupplementation with intra-articular hyaluronic acid may be prescribed to replenish the concentration, the molecular weight and the rheological properties of natural synovial fluid. The present review concentrates on the recent advancements in viscosupplementation with emphasis into their rheological properties, its effects on the rheological behavior of synovial fluid, and finally its clinical effectiveness. Initially, the properties of synovial fluid are summarized, and then a discussion on commercial viscosupplements, the role of polymeric properties and their rheological properties are reviewed. Moreover, a detailed discussion on the clinical effectiveness and challenges of viscosupplements are provided.

Address: School of Mechanical Engineering, Lovely Professional University, Punjab, India.; Central Research Institute (H), Noida, India.; Indian Institute of Technology (Indian School of Mines) Dhanbad, India.; Institute for Bio-Economy and Agri-Technology, Center for Research and Technology Hellas, 38333 Volos, Greece.; Department of Mechanical Engineering, University of West Attica, 12210 Athens, Greece. Electronic address: [email protected].

DOI: 10.1016/j.cmpb.2020.105644

Link outs

Free resources

Medical:

https://medlineplus.gov/osteoarthritis.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Hyaluronic Acid, Injections, Intra-Articular, Osteoarthritis, Synovial Fluid, Viscosity, Viscosupplements