Genotoxic effects of mycotoxins.

Taha Gökmen Ülger, Aslı Uçar, Funda Pınar Çakıroğlu, Serkan Yilmaz

Journal: Toxicon : official journal of the International Society on Toxinology 2020;185():104-113

PMID: 32653416

Full Text on Elsevier Science View on PubMed

Abstract

Fungi produce mycotoxins in the presence of appropriate temperature, humidity, sufficient nutrients and if the density of the mushroom mass is favorable. Although all mycotoxins are of fungal origin, all toxic compounds produced by fungi are not called mycotoxins. The interest in mycotoxins first started in the 1960s, and today the interest in mycotoxin-induced diseases has increased. To date, 400 mycotoxins have been identified and the most important species producing mycotoxins belongs to Aspergillus, Penicillium, Alternaria and Fusarium genera. Mycotoxins are classified as hepatotoxins, nephrotoxins, neurotoxins, immunotoxins etc. In this review genotoxic and also other health effects of some major mycotoxin groups like Aflatoxins, Ochratoxins, Patulin, Fumonisins, Zearalenone, Trichothecenes and Ergot alkaloids were deeply analyzed.

Address: Bolu Abant İzzet Baysal University, Faculty of Health Sciences, Gölköy Campus, 14030, Bolu, Turkey.; University of Ankara, Faculty of Health Sciences, Department of Nutrition and Dietetics, Fatih Street, No: 197/A 06290, Keçiören, Ankara, Turkey.; University of Ankara, Faculty of Nursing, Department of Midwifery, Plevne Street, No: 5, 06230, Altındağ, Ankara, Turkey; University of Ankara, Faculty of Health Sciences, Fatih Street No: 197/A 06290 Keçiören/ankara, Turkey. Electronic address: [email protected].

DOI: 10.1016/j.toxicon.2020.07.004

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MeSH Terms: Aflatoxins, Aspergillus, DNA Damage, Food Contamination, Food Microbiology, Fumonisins, Fungi, Fusarium, Mutagens, Mycotoxins, Ochratoxins, Patulin, Trichothecenes, Zearalenone