Beyond thrombosis: the impact of tissue factor signaling in cancer.

Dusten Unruh, Craig Horbinski

Journal: Journal of hematology & oncology 2021;13(1):93

PMID: 32665005

Free Full Text on BioMed Central View on PubMed

Abstract

Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave transmembrane G protein-coupled protease-activated receptors (PARs). In addition to activating PARs, TF:FVIIa complex can also activate receptor tyrosine kinases (RTKs) and integrins. These signaling pathways are utilized by tumors to increase cell proliferation, angiogenesis, metastasis, and cancer stem-like cell maintenance. Herein, we review in detail the regulation of TF expression, mechanisms of TF signaling, their pathological consequences, and how it is being targeted in experimental cancer therapeutics.

Address: Department of Neurological Surgery, Northwestern University, 303 East Superior St, Chicago, IL, 60611, USA. [email protected].; Department of Neurological Surgery, Northwestern University, 303 East Superior St, Chicago, IL, 60611, USA.; Department of Pathology, Northwestern University, Chicago, IL, 60611, USA.

DOI: 10.1186/s13045-020-00932-z

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/cancer.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-71

MeSH Terms: Amino Acid Sequence, Cell Hypoxia, Factor VIIa, Gene Expression Regulation, Neoplastic, Humans, Immunotherapy, Adoptive, Integrins, Molecular Sequence Data, Molecular Targeted Therapy, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Proteins, Neoplasms, Neoplastic Stem Cells, Neovascularization, Pathologic, Protein Conformation, Protein Domains, Protein Isoforms, Receptor Protein-Tyrosine Kinases, Receptors, Proteinase-Activated, Signal Transduction, Thrombophilia, Thromboplastin