lncRNA ZEB2-AS1: A promising biomarker in human cancers.

Zarei Mahboobeh, Mousavi Pegah, Sadri Fatemeh, Karimi Elham, Azari Hanieh, Rafat Milad, Shekari Mohammad

Journal: IUBMB life 2021;72(9):1891-1899

PMID: 32687675

Abstract

Long non-coding RNAs (lncRNAs) are one of the ncRNAs that transcript with length more than 200 nt that are not translated into protein. Studies have shown that lncRNAs have regulatory function in human disease especially cancers. lncRNA dysfunction causes altered cellular behavior including proliferation, invasion, and migration, and also it can inhibit apoptosis. Long non-coding zinc finger E-box binding homeobox 2 antisense RNA1 (lnZEB2-AS1) is one of the lncRNAs that plays the oncogenic role in different cancers. Dysregulation of lncZEB2-AS1 can lead to tumorigenesis and cancer progression. lncZEB2-AS1 may be introduced as a diagnostic marker or therapeutic target for human cancers. In this review, we describe briefly the mechanism of ZEB2-AS1 in cells and its function in cancer progression.

Address: Department of Medical Genetics, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

DOI: 10.1002/iub.2338

Link outs

Free resources

Full Text Sources:

https://onlinelibrary.wiley.com/doi/10.1002/iub.23...

Medical:

https://medlineplus.gov/cancer.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-ZEB2-1

MeSH Terms: Apoptosis, Cell Proliferation, Epithelial-Mesenchymal Transition, Humans, Neoplasms, RNA, Antisense, RNA, Long Noncoding, Zinc Finger E-box Binding Homeobox 2