Autophagy-related MicroRNAs in chronic lung diseases and lung cancer.

Mohsen Moghoofei, Hamed Mirzaei, Maryam Mahjoubin-Tehran, Samaneh Rezaei, Amin Jalili, Seyed Hamid Aghaee-Bakhtiari, Ahmad Movahedpour, Haroon Khan, Zahra Shojaei, Michael R Hamblin

Journal: Critical reviews in oncology/hematology 2020;153():103063

PMID: 32712519

Full Text on Elsevier Science View on PubMed

Abstract

Chronic lung disease has become a leading cause of death in recent years. Despite several attempts to discover and develop new therapeutic approaches, patients often suffer a poor quality of life, and are faced with an increased risk of developing lung cancer. Lung cancer often occurs as an end-stage after years of chronic lung disease. An increased understanding of the pathophysiology of chronic lung disease may be obtained from studying the role of autophagy in its initiation and progression. MicroRNAs (miRNAs) play a critical role in the modulation of autophagy, and their deregulation could be associated with the initiation and progression of several chronic lung diseases. Herein, we documented that up/down regulation of miRNAs can activate or inhibit autophagy in chronic lung diseases including lung cancer. Therefore, theses miRNAs could be a promising therapeutic tool for lung cancer specially in drug-resistance lung cancer cells.

Address: Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Bioinformatics Research Group, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Biotechnology, School of Advanced Medical Sciences & Technologies, Shiraz University of Medical Sciences Shiraz, Iran.; Department of Pharmacy, Abdul Wali Khan University Mardan 23200. Iran.; Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, Boston, MA 02114, USA; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected].

DOI: 10.1016/j.critrevonc.2020.103063

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MeSH Terms: Autophagy, Humans, Lung, Lung Diseases, Lung Neoplasms, MicroRNAs, Quality of Life