Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone.

Wen Zhu, Judith P Klinman

Journal: Current opinion in chemical biology 2021;59():93-103

PMID: 32731194

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Abstract

Pyrroloquinoline quinone (PQQ) is a peptide-derived redox cofactor produced by prokaryotes that also plays beneficial roles in organisms from other kingdoms. We review recent developments on the pathway of PQQ biogenesis, focusing on the mechanisms of PqqE, PqqF/G, and PqqB. These advances may shed light on other, uncharacterized biosynthetic pathways.

Address: California Institute for Quantitative Biosciences and Department of Chemistry, University of California, Berkeley, CA, 94720-3220, USA.; California Institute for Quantitative Biosciences and Department of Chemistry, University of California, Berkeley, CA, 94720-3220, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720-3220, USA. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2020.05.001

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MeSH Terms: Bacteria, Bacterial Proteins, Biosynthetic Pathways, Models, Molecular, Oxidation-Reduction, PQQ Cofactor