Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease.

Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Marzena Skrzypczak-Zielińska, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak

Journal: Nutrients 2021;12(8):2263

PMID: 32751086

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Abstract

Recent research studies have shown that vitamin C (ascorbic acid) may affect bone mineral density and that a deficiency of ascorbic acid leads to the development of osteoporosis. Patients suffering from an inflammatory bowel disease are at a risk of low bone mineral density. It is vital to notice that patients with Crohn's disease and ulcerative colitis also are at risk of vitamin C deficiency which is due to factors such as reduced consumption of fresh vegetables and fruits, i.e., the main sources of ascorbic acid. Additionally, some patients follow diets which may provide an insufficient amount of vitamin C. Moreover, serum vitamin C level also is dependent on genetic factors, such as and genes, encoding sodium-dependent vitamin C transporters and , and genes which encode glutathione S-transferases. Furthermore, ascorbic acid may modify the composition of gut microbiota which plays a role in the pathogenesis of an inflammatory bowel disease.

Address: Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.

DOI: 10.3390/nu12082263

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Full Text Sources:

Medical:

https://medlineplus.gov/vitaminc.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3574

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-GST+Mu1-...

MeSH Terms: Ascorbic Acid, Ascorbic Acid Deficiency, Bone Density, Colitis, Ulcerative, Crohn Disease, Diet, Female, Gastrointestinal Microbiome, Glutathione S-Transferase pi, Glutathione Transferase, Humans, Inflammatory Bowel Diseases, Male, Osteoporosis, Risk Factors, Sodium-Coupled Vitamin C Transporters