Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes.

Katarzyna Gałczyńska, Zuzanna Drulis-Kawa, Michał Arabski

Journal: Molecules (Basel, Switzerland) 2021;25(15):3492

PMID: 32751963

Abstract

Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review.

Address: Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.; Department of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wroclaw, Przybyszewskiego 63-77, 51-148 Wrocław, Poland.

DOI: 10.3390/molecules25153492

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MeSH Terms: Antineoplastic Agents, Apoptosis, Autophagy, Cell Cycle, Cobalt, Coordination Complexes, Copper, DNA, DNA Damage, Humans, Nickel, Organometallic Compounds, Platinum Compounds, Proteasome Inhibitors, Ruthenium Compounds