An Update on the Role of Total-Body PET Imaging in the Evaluation of Atherosclerosis.

Austin J Borja, Chaitanya Rojulpote, Emily C Hancin, Poul Flemming Høilund-Carlsen, Abass Alavi

Journal: PET clinics 2021;15(4):477-485

PMID: 32888546

Abstract

Fused PET/computed tomography has demonstrated success in the detection and quantification of atherosclerotic plaques. Recently, total-body PET imaging has demonstrated increased sensitivity and specificity in atherosclerosis. This article reviews the literature regarding this novel imaging technique. Moreover, evidence that has pointed toward 18F-sodium fluoride as the radiotracer of choice over 18F-fluorodeoxyglucose for evaluation of plaque burden is discussed. Finally, a global disease assessment is introduced as an adjunct tool for vascular PET imaging.

Copyright © 2020 Elsevier Inc. All rights reserved.

Address: Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Department of Internal Medicine, The Wright Center for Graduate Medical Education, 501 S Washington Ave Suite 1000, Scranton, PA 18505, USA.; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Lewis Katz School of Medicine at Temple University, 3500 N Broad St, Philadelphia, PA 19140, USA.; Department of Nuclear Medicine, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3. salOdense C - DK-5000, Denmark.; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: [email protected].
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