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Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial.

Elizabeth S McDonald, Robert K Doot, Austin R Pantel, Michael D Farwell, Robert H Mach, Kara N Maxwell, David A Mankoff

Journal: JAMA oncology 2021;6(6):921-923

PMID: 32297911

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Abstract

This nonrandomized clinical trial tested [F]FluorThanatrace as a method for measuring regional poly–(adenosine diphosphate–ribose) polymerase 1 expression in breast cancer and as a potential functional biomarker for breast cancer poly–(adenosine diphosphate–ribose) polymerase inhibitor response.

Address: Department of Radiology, University of Pennsylvania, Philadelphia.; Department of Medicine, University of Pennsylvania, Philadelphia.
DOI: 10.1001/jamaoncol.2020.0334

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MeSH Terms: Breast Neoplasms, Female, Fluorine Radioisotopes, Humans, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerase Inhibitors, Positron-Emission Tomography
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