Regulating the regulator: nitric oxide control of post-translational modifications.

Kapuganti Jagadis Gupta, Zsuzsanna Kolbert, Jorg Durner, Christian Lindermayr, Francisco J Corpas, Renaud Brouquisse, Juan B Barroso, Saima Umbreen, José M Palma, John T Hancock, Marek Petrivalsky, David Wendehenne, Gary J Loake

Journal: The New phytologist 2021;227(5):1319-1325

PMID: 32339293

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Abstract

Nitric oxide (NO) is perfectly suited for the role of a redox signalling molecule. A key route for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to a protein cysteine (Cys) thiol (-SH) to form an S-nitrosothiol (SNO). This process is thought to underpin a myriad of cellular processes in plants that are linked to development, environmental responses and immune function. Here we collate emerging evidence showing that NO bioactivity regulates a growing number of diverse post-translational modifications including SUMOylation, phosphorylation, persulfidation and acetylation. We provide examples of how NO orchestrates these processes to mediate plant adaptation to a variety of cellular cues.

Address: National Institute of Plant Genome Research Aruna Asaf Ali Mar, 110067, New Delhi, India.; Department of Plant Biology, University of Szeged, Szeged, 6726, Hungary.; Institute of Biochemical Plant Pathology, Helmholtz Zentrum München - German Research Center for Environmental Health, München/Neuherberg, 85764, Germany.; Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry and Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), Profesor Albareda 1, 18008, Granada, Spain.; Institut Sophia Agrobiotech, INRAE, CNRS, Université Côte d'Azur, 06903, Sophia Antipolis Cedex, France.; Group of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils, Faculty of Experimental Sciences, University of Jaén, Campus Universitario 'Las Lagunillas' s/n, Jaén, 23071, Spain.; Institute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3BF, UK.; Department of Applied Sciences, University of the West of England, Bristol, BS16 1QY, UK.; Department of Biochemistry, Faculty of Science, Palacký University, Šlechtitelů 27, CZ-783 71, Olomouc, Czech Republic.; Agroécologie, AgroSup Dijon, CNRS, INRAE, Univ. Bourgogne Franche-Comté, 21000, Dijon, France.

DOI: 10.1111/nph.16622

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MeSH Terms: Nitric Oxide, Nitrosation, Oxidation-Reduction, Plants, Protein Processing, Post-Translational, S-Nitrosothiols