Recent Progress of Nanozymes in the Detection of Pathogenic Microorganisms.

Huiyuan Sun, Shuangfei Cai, Chen Wang, Yongxiang Chen, Rong Yang

Journal: Chembiochem : a European journal of chemical biology 2021;21(18):2572-2584

PMID: 32352212

Abstract

Infectious diseases are among the world's principal health problems. It is crucial to develop rapid, accurate and cost-effective methods for the detection of pathogenic microorganisms. Recently, considerable progress has been achieved in the field of inorganic enzyme mimics (nanozymes). Compared with natural enzymes, nanozymes have higher stability and lower cost. More interestingly, their properties can be designed for various demands. Herein, we introduce the latest research progress on the detection of pathogenic microorganisms by using various nanozymes. We also discuss the current challenges of nanozymes in biosensing and provide some strategies to overcome these barriers.

Address: CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Center of Materials Science and Optoelectronics Engineering, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, UCAS, Beijing, 100190, P. R. China.; Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.; Sino-Danish College, UCAS, Sino-Danish Center for Education and Research, Beijing, 100190, P. R. China.

DOI: 10.1002/cbic.202000126

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https://doi.org/10.1002/cbic.202000126

MeSH Terms: Bacteria, Biomimetic Materials, Biosensing Techniques, Communicable Diseases, Nanostructures