Eosinophilic Esophagitis.

David A Katzka

Journal: Annals of internal medicine 2020;172(9):ITC65-ITC80

PMID: 32365374

Abstract

Eosinophilic esophagitis (EoE) is a relatively new disease that has reached an incidence similar to that of Crohn disease and ulcerative colitis. With this increased presence, greater recognition is essential. This applies both to children with nonspecific but potentially debilitating symptoms and to adults who have spent years behaviorally compensating for narrow esophageal strictures. The pathogenesis of EoE is rapidly being unraveled and is based on initiation of a type II allergic response to specific food antigens, leading to dense esophageal eosinophilia, chronic inflammation, and esophageal fibrosis. With greater familiarity and understanding of EoE, treatments are evolving, including identification and avoidance of food antigens; broad applications of topical steroids; and, eventually, pathway-specific biologic therapy.

Address: Mayo Clinic, Rochester, Minnesota (D.A.K.).

DOI: 10.7326/AITC202005050

Link outs

Free resources

Medical:

https://medlineplus.gov/eosinophilicesophagitis.ht...

Subscription / membership required

Full Text Sources:

MeSH Terms: Allergists, Biopsy, Deglutition Disorders, Diagnosis, Differential, Diet Therapy, Dilatation, Eosinophilic Esophagitis, Esophageal Stenosis, Esophagoscopy, Esophagus, Genetic Predisposition to Disease, Glucocorticoids, Humans, Hypersensitivity, Immunoglobulin G, Nutritionists, Practice Guidelines as Topic, Prevalence, Proton Pump Inhibitors, Quality of Life