A new diterpene and bioactivities of labdanes isolated from .

Edith Fabiola Martínez-Pérez, Eleuterio Burgueño-Tapia, Samuel Roa-Flores, Aranza E Bendaña-Piñeiro, Eugenio Sánchez-Arreola, Horacio Bach, Luis Ricardo Hernández

Journal: Natural product research 2021;36(1):71-78

PMID: 32375531

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Abstract

The new labdane [(3R*,4aR*,7S*,10aS*,10bR*)-3-ethenyl-3,4a,7,10a-tetramethyl-dodecahydro-1H-naphtho-[2,1-b]-pyran-7-yl]-methylbenzoate together with other 7 labdanes were isolated from the aerial parts of . Compound structures were elucidated by spectroscopic methods. Some compounds showed moderate to weak antimicrobial activity towards a panel of bacterial and fungal pathogens. In addition, -biformene (2) and ribenol acetate (8) showed to be highly cytotoxic with LC50 < 1 µg/mL, the other compounds showed moderate cytotoxic effect with a LC50 range of 6.008-15.26 µg/mL. For all isolated compounds, no inflammatory response was observed.

Address: Departamento de Ciencias Químico Biológicas, Universidad de las Américas Puebla, San Andrés Cholula, Puebla, Mexico.; Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.; Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, Mexico.; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada.; Sección de Patología Experimental, Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México, Mexico.

DOI: 10.1080/14786419.2020.1762184

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MeSH Terms: Bacteria, Buddleja, Diterpenes, Fungi, Humans, Plant Extracts, THP-1 Cells